340P Prediction of relapse in colon cancer patients by machine learning models combining radiomics and deep features extracted from baseline computed tomography
نویسندگان
چکیده
Up to 40% of localized colon cancer (CC) patients relapse despite optimal initial treatment. Circulating tumor DNA has emerged as a new prognostic biomarker in this setting. However, liquid biopsy tests provide limited accuracy the early prediction relapse. On basis, radiomics and artificial intelligence (AI) are posed relevant insights patient outcome. Here we propose predictive model CC recurrence using clinical data combination with deep features extracted from baseline computed tomography (CT) images. A single-center retrospective observational study was designed. Real-world CT examinations were collected 2015 2017. Manual segmentation performed slice by radiologist 10+ years experience ITK-SNAP. Feature extraction techniques applied voxels through an analysis pipeline Python adapted Quibim Precision® software (Quibim, Valencia, ES). reduction select characteristics providing independent information. The types were: Radiomics, Deep fractal dimension. Several classifiers trained image input, predict CC. Relapse non-relapse classes balanced number slices containing tumor. Train-validation ratio 70:30. Baseline exams 60 included. 48% 20% them had stage III high-risk II, respectively. remaining diagnosed low-risk 36.7% relapsed. Merging radiomics, provided high increased 95% (CI 95%: 85 – 100) when compared variables alone (55%, CI 32 78). Random Forest cross validation best performance. their AI promising towards relapse, leading identify accurate imaging panels.
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2022
ISSN: ['0923-7534', '1569-8041']
DOI: https://doi.org/10.1016/j.annonc.2022.07.478